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. 2018 Aug 17;8:12315. doi: 10.1038/s41598-018-30947-z

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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In vivo transduction efficiencies of FX-pre-coated Ad-L2 in the liver following intravenous administration in warfarinized mice. Plasmid DNA-immunized and non-immunized mice were warfarinized before administration of an Ad vector. Ad-L2 and FX were mixed and incubated for 30 min before administration. FX-pre-coated Ad-L2 was intravenously administered to mice at a dose of 1 × 10¹⁰ VP/mouse. Luciferase production levels in the liver were determined 48 h after administration. The data are expressed as the mean ± S.D. (n = 6). ***p < 0.001.