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. 2018 Aug 17;8:12369. doi: 10.1038/s41598-018-30791-1

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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RNAseq analysis of MEFs expressing Multicilin and E2f4VP16. (a–d) Shown are volcano plots of genes that are significantly changed (p < 0.05) in expression in MEFs expressing Multicilin/E2f4VP16 versus MEFs expressing GFP, 2 days PI. Both MEFs were serum starved to promote exit from the cell cycle prior to infection. Genes are marked in red that also change during MCC differentiation in Xenopus skin progenitors (a), that are mutated in PCD (b)⁶³, that are associated with centriole biogenesis (c)²², and that are regulated by E2f4/RB during the cell cycle (d)⁴⁹ (Table S1).