Table 2.

Hazard ratios and 95% confidence intervals for mosaic loss of the Y chromosome (mLOY) and all-cause mortality using age as the underlying time metric (N = 223, 338).

	mLOY (mLRR <−0.15)			mLOY (mLRR <−0.40)			mLRRd
	HR	95% CI	P-value	HR	95% CI	P-value	HR	95% CI	P-value
N (%) with mLOY	3,789 (1.70)			596 (0.27)
No. deaths	8401			8401			8401
No. deaths with mLOY	334			75
Age-adjusteda	1.37	(1.23–1.53)	1.7 × 10−8	1.88	(1.50–2.36)	6.0 × 10−8	1.06	(1.04–1.08)	9.0 × 10−12
Age- & smoking-adjustedb	1.06	(0.95–1.18)	0.31	1.35	(1.08–1.70)	0.01	1.01	(0.99–1.03)	0.24
Multivariable-adjustedc	1.08	(0.97–1.21)	0.16	1.35	(1.08–1.70)	0.009	1.02	(1.00–1.03)	0.07

^aAdjusted for age using age as the underlying time metric in the Cox proportional hazards regression model.

^bAdditionally adjusted for detailed smoking history (25-level variable incorporating current smoking status, smoking intensity (current and former smokers); time since quitting (former smokers), and cigar and pipe use (current and former smokers).

^cAdditionally adjusted for race/ethnicity (white, black, Asian, mixed, or other race); alcohol drinking (never drinker, former drinker, infrequent drinker (<1 drink/week), occasional drinker (>1 drink/week but <1 drink/day), moderate daily drinker (1 to 3 drinks/day), or heavy daily drinker (>3 drinks/day)); general health status (excellent, good, fair, or poor); education level (college or university degree, A levels/AS levels or equivalent, O levels/GCSEs or equivalent, CSEs or equivalent, NVQ or HND or HNC equivalent, or other professional qualifications); body mass index (<18.5, 18.5 to <25, 25 to <30, 30 to <35, or ≥35 kg/m²); and physical activity (>10 minutes of moderate of vigorous activity 0, 1-2, 3-4, or ≥5 days/week).

^dScaled by the - (standard deviation) of mLRR such that the HR corresponds to a one standard deviation decrease in mLRR. Abbreviations: CI, confidence interval; HR, hazard ratio; mLOY, mosaic loss of the Y chromosome; mLRR, median log₂ intensity ratio of the Y chromosome.