Table 4.
Hazard ratios and 95% confidence intervals for mosaic loss of the Y chromosome and all-cause mortality using age as the underlying time metric and stratified by baseline characteristics.
| mLOY (mLRR <−0.15) | mLOY (mLRR <−0.40) | mLRR d | |||||||
|---|---|---|---|---|---|---|---|---|---|
| HR | 95% CI | P-value | HR | 95% CI | P-value | HR | 95% CI | P-value | |
| Age a | |||||||||
| <65 years | 1.15 | (0.97–1.37) | 0.10 | 1.43 | (0.96–2.12) | 0.08 | 1.01 | (0.99–1.04) | 0.43 |
| ≥65 years | 1.05 | (0.91–1.22) | 0.51 | 1.35 | (1.02–1.79) | 0.04 | 1.02 | (1.00–1.05) | 0.04 |
| Smoking status b | |||||||||
| Never smoker | 0.90 | (0.67–1.22) | 0.50 | 1.10 | (0.52–2.32) | 0.80 | 1.00 | (0.96–1.04) | 0.91 |
| Former smoker | 1.20 | (1.02–1.40) | 0.03 | 1.43 | (1.02–2.02) | 0.04 | 1.03 | (1.00–1.05) | 0.03 |
| Current smoker | 1.19 | (1.00–1.43) | 0.06 | 1.51 | (1.08–2.11) | 0.02 | 1.03 | (1.01–1.06) | 0.02 |
| Self-reported health c | |||||||||
| Excellent/Good | 1.08 | (0.92–1.26) | 0.35 | 1.34 | (0.96–1.87) | 0.09 | 1.01 | (0.99–1.04) | 0.35 |
| Fair/Poor | 1.06 | (0.91–1.24) | 0.47 | 1.36 | (0.99–1.86) | 0.06 | 1.02 | (0.99–1.04) | 0.17 |
aMultivariable model is adjusted for age (as the underlying time metric), detailed smoking history (25-level variable incorporating current smoking status, smoking intensity (current and former smokers); time since quitting (former smokers), and cigar and pipe use (current and former smokers)); time to first cigarette among current smokers (<5 minutes, 5 to 15 minutes, 30 minutes to 1 hour, or >1 hour)); race/ethnicity (white, black, Asian, mixed, or other race); alcohol drinking (never drinker, former drinker, infrequent drinker (<1 drink/week), occasional drinker (>1 drink/week but <1 drink/day), moderate daily drinker (1 to 3 drinks/day), or heavy daily drinker (>3 drinks/day); general health status (excellent, good, fair, or poor); education level (college or university degree, A levels/AS levels or equivalent, O levels/GCSEs or equivalent, CSEs or equivalent, NVQ or HND or HNC equivalent, or other professional qualifications); body mass index (<18.5, 18.5 to <25, 25 to <30, 30 to <35, or ≥35 kg/m2); and physical activity (>10 minutes of moderate of vigorous activity 0, 1-2, 3-4, or ≥5 days/week).
bSmoking stratified models were not adjusted for detailed smoking history.
cSelf-reported health stratified models were not adjusted for self-reported health.
dScaled by the - (standard deviation) of mLRR such that the HR corresponds to a one standard deviation decrease in mLRR. Abbreviations: CI, confidence interval; HR, hazard ratio; mLOY, mosaic loss of the Y chromosome; mLRR, median log2 intensity ratio of the Y chromosome.