Table 2.

Overrepresented signaling pathways of DOCK8 interacting proteins in PBL of healthy controls.

Signaling pathway	p-value	No. of proteins observed	List of observed proteins (gene symbols)
ARP2 Actin Related Protein 2 Homolog (Yeast)	3,85E-08	6	ACTR2, GSN, VCL, ACTB, ARPC4, ACTR3
Small GTP-binding Protein RAC	3,13E-04	8	ACTR2, FERMT3, RSU1, DOCK8, CORO1C, IQGAP1, C1QA, PARVB
Myosin light chain kinase	6,35E-04	4	ACTN1, MYO18A, MYH10, MYL9

List of the top 3 significantly (p-value) enriched signaling pathways containing DOCK8-interacting proteins enriched in healthy PBL (≥2 peptide counts; enrichment factor ≥4) analyzed by Genomatix (version 3.7).