Table 3.
Overrepresented signaling pathways of DOCK8 interacting proteins in PBL of ERU cases.
Signaling pathway | p-value | No. of proteins observed | List of observed proteins (gene symbols) |
---|---|---|---|
ARP2 Actin Related Protein 2 Homolog (Yeast) | 8,39E-06 | 6 | VCL, ARPC4, CAPZA1, ACTR3, GSN, ACTB |
Integrin | 3,87E-04 | 12 | LGALS3BP, ITGB3, VCL, FLNA, FN1, C3, TRF, VWF, ACTN1, TLN1, ILK, C1QA |
Cofilin | 1,44E-03 | 8 | MYO9B, HSPB1, SEPT7, NEXN, PHB, GSN, SEPT2, ACTB |
List of the top 3 significantly (p-value) enriched signaling pathways containing DOCK8-interacting proteins enriched in ERU PBL (≥2 peptide counts; enrichment factor ≥4) analyzed by Genomatix (version 3.7).