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. 2018 Aug 17;8:12398. doi: 10.1038/s41598-018-30098-1

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Ang II-induced hypertension and LVH in rats. (A) Blood pressure in Ang II treated and vehicle treated rats. (B) Cardiac hypertrophy as measured by heart weight/ body weight ratio in Ang II treated and vehicle treated rats. (C) Ang II increased the expression of the genes related to hypertrophy in the rat heart. (D) Serum concentrations of creatinine (D), ACE2 (E) and FGF-23 (F) in Ang II and vehicle treated rats. Animals treated with Ang II (35 μg/kg/h by minipump) or vehicle (saline) infusion for four weeks (n = 5/group). *p < 0.05 vs vehicle treated controls. All values are shown as mean ± SEM.