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. 2018 Aug 17;8:12398. doi: 10.1038/s41598-018-30098-1

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Increased FGF-23 is associated with LVH in Hyp mice. Comparison of serum FGF-23 levels (A), cardiac hypertrophy (B), and serum aldosterone levels (C) in Hyp and wild type mice at age of 20 or 40 weeks old. (D) Comparison of Fgf-23 expression in heart, kidney and bone (without marrow) from Hyp and wild type mice at age of 20 weeks old. (E) Comparison of gene expression markers of cardiac hypertrophy in heart from Hyp and wild type mice at age of 20 weeks old. (F) Comparison of FGF-23 regulated genes expression in the kidney from Hyp and wild type mice at age of 20 weeks old. (G) Comparison of α-Kl expression in heart, kidney and bone (without marrow) from Hyp and wild type mice at age of 20 weeks old. n = 4/group, *p < 0.05 vs vehicle treated controls. All values are shown as mean ± SEM.