Fig 1.

Clinical response of patient 1 to treatment with 5FU and cryotherapy. A, Clinical image, initial presentation. Numerous eroded, exophytic, bleeding, and friable plaques affecting the back, chest, and abdomen of patient 1 before treatment with 5FU and cryotherapy. B, Clinical image, 4-month follow-up. Significant clinical response, most prominent over the right side of the abdomen of patient 1 after 4 months of skin-directed treatment combined with systemic letrozole and radiation.