Fig 3.

Clinical response of patient 3 to fluorouracil and cryotherapy. A, Clinical image, metastatic progression. Ulcerated plaque at mastectomy site with multiple surrounding metastatic papules coalescing in to plaques on bilateral breasts and upper chest of patient 3 after 4 weeks of skin-directed therapy. B, Clinical image, 5-month follow up. Complete clinical response of cutaneous metastases of patient 3 within 4 months of combined topical and systemic therapy with 5FU, cryotherapy, docetaxel, pertuzumab, trastuzumab, and radiation.