Table 1.

Sperm abnormality test for vitacoxib in mice.

Parameters		Group (mg/kg)
		high-dose	medium-dose	low-dose	Negative	Positive
Number of mice		5	5	5	5	5
Number of sperm observed		5 × 1000	5 × 1000	5 × 1000	5 × 1000	5 × 1000
Number of sperm abnormality		96	110	103	104	369
Abnormal ratio (%)		1.96 ± 0.0.66	2.25 ± 0.68	2.10 ± 0.90	2.12 ± 0.72	7.99 ± 2.76
significance of difference		P>0.05	P>0.05	P>0.05	–	P<0.01
Abnormal sperms counted ratio (%)	No hook	12.50 ± 1.00	13.64 ± 0.64	11.65 ± 0.60	11.54 ± 0.60	8.40 ± 1.32
	Banana shape	14.58 ± 0.79	10.00 ± 0.51	9.71 ± 0.61	12.50 ± 0.67	6.23 ± 0.99
	amorphous	41.67 ± 0.89	39.09 ± 1.09	36.89 ± 1.02	39.42 ± 1.00	53.39 ± 4.76
	Large round head	12.50 ± 0.12	10.91 ± 0.60	10.68 ± 0.51	6.73 ± 0.49	11.38 ± 1.86
	Kinks tail	7.29 ± 0.74	8.18 ± 0.60	2.91 ± 0.37	5.77 ± 0.47	4.07 ± 0.64
	Two head	2.08 ± 1.00	2.73 ± 0.37	4.85 ± 0.44	1.92 ± 0.50	3.25 ± 0.75
	Two tails	9.38 ± 0.01	15.45 ± 0.67	23.23 ± 0.89	22.12 ± 1.04	13.28 ± 1.76

Note: No significance of difference was observed that all treatment groups compared with negative control group.

Low dose = 1250 mg/kg bw; Medium dose = 2500 mg/kg bw; High dose = 5000 mg/kg bw.