Table 2.
Effects of vitacoxib on mouse bone marrow micronucleus and PCE/RBC ratio.
| Sex | Dose (mg/kg) | PCE/RBC | PCE micronucleus (‰) | P |
|---|---|---|---|---|
| Female | high-dose | 0.89 ± 0.04 | 1.43 ± 1.97 | P>0.05 |
| medium-dose | 0.86 ± 0.06 | 1.72 ± 2.13 | P>0.05 | |
| low-dose | 0.91 ± 0.09 | 1.80 ± 2.01 | P>0.05 | |
| Negative | 0.80 ± 0.07 | 1.62 ± 2.22 | – | |
| Positive | 0.45 ± 0.04 | 14.70 ± 5.52 | P<0.01 | |
| Male | high-dose | 0.90 ± 0.06 | 1.01 ± 1.97 | P>0.05 |
| medium-dose | 0.83 ± 0.07 | 1.99 ± 2.64 | P>0.05 | |
| low-dose | 0.80 ± 0.06 | 1.40 ± 2.15 | P>0.05 | |
| Negative | 0.82 ± 0.08 | 1.45 ± 2.23 | – | |
| Positive | 0.47 ± 0.06 | 12.92 ± 7.04 | P<0.01 | |
Note: No significance of difference was observed that all treatment groups compared with negative control group. RBC: red blood cells; PCE: poly-chromatic erythrocytes.
Low dose = 1250 mg/kg bw; Medium dose = 2500 mg/kg bw; High dose = 5000 mg/kg bw.