Table 3.
Summary of chromosomal aberration frequencies in the bone marrow of the male and female mice dosed with vitacoxib.
| Sex | Dose(mg/kg) | Number of mice | Number of cells at metaphase | Number of cells with chromosome aberration | Chromosome aberration (%) | P |
|---|---|---|---|---|---|---|
| Female | high-dose | 5 | 5 × 100 | 5 | 1.0 ± 0.45 | P>0.05 |
| medium-dose | 5 | 5 × 100 | 5 | 1.0 ± 0.45 | P>0.05 | |
| low-dose | 5 | 5 × 100 | 4 | 0.8 ± 0.40 | P>0.05 | |
| Negative | 5 | 5 × 100 | 6 | 1.2 ± 0.48 | – | |
| Positive | 5 | 5 × 100 | 203 | 40.6 ± 2.90 | P<0.01 | |
| Male | high-dose | 5 | 5 × 100 | 5 | 0.8 ± 0.42 | P>0.05 |
| medium-dose | 5 | 5 × 100 | 4 | 0.8 ± 0.40 | P>0.05 | |
| low-dose | 5 | 5 × 100 | 5 | 1.0 ± 0.45 | P>0.05 | |
| Negative | 5 | 5 × 100 | 4 | 0.8 ± 0.42 | – | |
| Positive | 5 | 5 × 100 | 196 | 39.2 ± 2.60 | P<0.01 | |
Note: No significance of difference was observed that all treatment groups compared with negative control group.
Low dose = 1250 mg/kg bw; Medium dose = 2500 mg/kg bw; High dose = 5000 mg/kg bw.