Table 4.

Effects of vitacoxib on the daily body weight gain, food consumption and water intake during gestational day.

Parameter day (s) of pregnancy	Dose level (mg/kg/day)
	High-dose	Medium-dose	Low-dose	Control	Positive
Number of rats	12	12	12	12	12
Daily body weight gain M ± SD(g/rat/day)
Day 0–6	5.44 ± 0.54	5.33 ± 0.51	5.10 ± 0.76	5.00 ± 0.86	4.67 ± 0.52
Day 7–12	7.61 ± 0.76	7.46 ± 1.24	7.86 ± 1.06	7.50 ± 1.58	6.25 ± 0.79*
Day 13–20	5.98 ± 1.33	7.50 ± 1.70	7.43 ± 1.12	7.07 ± 1.58	6.49 ± 1.99
Day 0–20	6.32 ± 0.65	6.80 ± 0.96	6.83 ± 0.66	6.55 ± 0.53	5.84 ± 0.57*
Net gain	2.33 ± 0.33	2.52 ± 0.62	2.31 ± 0.44	2.49 ± 0.43	2.21 ± 0.42
Food consumption M ± SD(g/rat/day)
Day 0–6	19.88 ± 1.11	20.89 ± 1.18	20.66 ± 1.24	19.83 ± 1.38	21.51 ± 1.42
Day 7–12	28.60 ± 1.77	29.95 ± 1.75	29.14 ± 1.71	28.59 ± 1.44	26.68 ± 1.09
Day 13–20	36.82 ± 1.36	36.66 ± 1.45	36.11 ± 2.13	36.39 ± 1.48	36.52 ± 1.50
Water intake M ± SD(g/rat/day)
Day 0–6	43.71 ± 1.90	45.28 ± 2.59	45.17 ± 2.02	44.69 ± 1.81	45.10 ± 2.63
Day 7–12	50.74 ± 3.15	50.82 ± 4.25	52.36 ± 2.89	50.63 ± 2.63	51.13 ± 2.58
Day 13–20	67.16 ± 7.14	65.67 ± 4.80	63.18 ± 8.97	66.96 ± 6.95	66.71 ± 6.66

Note: No significance of difference was observed that all treatment groups compared with negative control group.

N, total of pregnant rats.

Low dose = 200 mg/kg bw; Medium dose = 1000 mg/kg bw; High dose = 5000 mg/kg bw; Positive = 300 mg/kg bw (aspirin).

^*Denote significance differences (P < 0.05).