FIG. 1.

Studies of glibenclamide pharmacokinetics (A) demonstrating immediate post-load levels of glibenclamide (3808 ± 611 pg/mL) and 4 day steady state concentrations (10170 ± 1823 pg/mL). Levels were not detectible in vehicle animals and are therefore not visible in the figure. Therapeutic levels did not influence normoglycemia. (B) Glucose levels were recorded in vehicle- and glibenclamide-treated animals at baseline, and at four subsequent time points: the end of the hemorrhagic shock phase, the end of the pre-hospital phase, the end of the hospital phase, and at 24 h. Glucose levels were not significantly different than in their vehicle counterparts, or than in naïve.