FIG. 3.

Continuous recordings of mean arterial pressure (A) were documented during the three phases of the combined injury experiments: hemorrhagic shock (shock, 35 min), pre-hospital phase (90 min), and hospital phase (15 min). Sodium concentration (B) and serum osmolarity (C) were also measured at the following time points: baseline, at the end of each phase of combined injury (“shock” at 35 min, “pre-hospital” at 125 min,“hospital” at 140 min), and at 24 h in the high-dose experiments. These measurements were performed comparing vehicle- with glibenclamide-treated animals for 24 h (A-i, B-i, C-i) and for 72 h (A-ii, B-ii, C-ii).