Table 2.
Basic information of included articles
lncRNA | Study | Country/source | Study design | Sample | Number | Stage | Cutoff | Method | Follow-up (months) | OS | HR (L/H) | HR (H/L) | 95% CI |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
AFAP1-AS1 | Feng et al3 | China | R | Frozen | 91 | I–IV | None | qRT-PCR | 66 | Multivariate | 3.32 | 1.55–5.90 | |
AFAP1-AS1 | Qiao et al4 | China | R | Frozen | 87 | I–IV | Median | qRT-PCR | 60 | Univariate | 1.88 | 1.01–3.52 | |
ANRIL | Zhang et al9 | China | R | Tissue | 120 | I–IV | 3 | qRT-PCR | 60 | Multivariate | 1.74 | 1.04–2.93 | |
ANRIL | Deng et al10 | China | R | Tissue | 100 | I–IV | None | qRT-PCR | .60 | Univariate | 1.61 | 0.95–2.74 | |
CASC15 | Yao et al18 | China | R | Tissue | 60 | I–IV | None | qRT-PCR | 60 | Univariate | 2.33 | 1.15–4.72 | |
CASC15 | Wu et al19 | China | R | Tissue | 88 | I–IV | Mean | qRT-PCR | 60 | Univariate | 1.70 | 0.84–3.47 | |
CCAT2 | Wang et al21 | China | R | Frozen | 85 | I–IV | Mean | qRT-PCR | 60 | Multivariate | 2.41 | 1.19–5.42 | |
CCAT2 | Wang et al22 | China | R | Frozen | 108 | I–IV | Median | qRT-PCR | 66 | Multivariate | 2.11 | 1.44–3.20 | |
GAPLINC | Hu et al32 | China | R | Tissue | 90 | I–IV | Median | RT-qPCR | .60 | Multivariate | 1.48 | 1.16–1.89 | |
GAPLINC | Liu et al33 | China | R | Frozen | 33 | None | 2.03 | qRT-PCR | 60 | Univariate | 1.77 | 0.57–5.52 | |
H19 | Li et al36 | China | R | Frozen | 74 | I–IV | Mean | qRT-PCR | 53 | Univariate | 2.26 | 0.58–8.86 | |
H19 | Zhang et al37 | China | R | Frozen | 80 | I–IV | Mean | qRT-PCR | 60 | Multivariate | 1.14 | 1.01–1.29 | |
H19 | Chen et al38 | China | R | Tissue | 128 | I–IV | 4.615 | qRT-PCR | 48 | Multivariate | 1.96 | 0.97–3.97 | |
H19 | Li et al29 | TCGA | R | Tissue | 361 | I–IV | None | Downloaded | .50 | Univariate | 1.79 | 1.26–2.53 | |
HOTAIR | Endo et al41 | China I | R | Frozen | 36 | I–IV | 1.0 | qRT-PCR | .60 | Univariate | 0.95 | 0.21–4.31 | |
China II | 32 | 5.12 | 0.96–27.18 | ||||||||||
HOTAIR | Xu et al42 | China | R | Frozen | 83 | I–IV | None | RT-qPCR | .72 | Multivariate | 2.13 | 1.00–4.50 | |
HOTAIR | Okugawa et al43 | Japan | R | Frozen | 150 | III–IV | 0.239 | RT-qPCR | 60 | Multivariate | 1.77 | 1.06–2.95 | |
HOTAIR | Liu et al44 | China | R | Both | 78 | II–IV | Median | qRT-PCR | >40 | Multivariate | 4.08 | 2.07–8.04 | |
HOTAIR | Zhang et al45 | China | R | Both | 50 | II–IV | Median | qRT-PCR | >45 | Univariate | 2.86 | 1.16–7.03 | |
HOTAIR | Zhao et al46 | China | R | Tissue | 168 | III–IV | Median | qRT-PCR | >60 | Multivariate | 1.47 | 1.04–2.06 | |
HOTAIR | Chen et al47 | China | R | Frozen | 65 | I–IV | 2.35 | qRT-PCR | >60 | Multivariate | 2.00 | 1.06–3.77 | |
HOTAIR | Feng and Huang48 | China | R | Tissue | 32 | None | None | qRT-PCR | >120 | Univariate | 1.52 | 0.45–5.14 | |
HOTAIR | Li et al49 | China | R | FFPE | 100 | I–IV | Mean | qRT-PCR | 90 | Univariate | 1.83 | 0.82–4.05 | |
HOTTIP | Ye et al50 | China | R | Frozen | 98 | I–III | Median | qRT-PCR | 60 | Univariate | 2.06 | 0.97–4.38 | |
HOTTIP | Yang et al51 | China | R | Frozen | 94 | I–III | Median | RT-qPCR | 54 | Univariate | 1.03 | 0.52–2.05 | |
HOTTIP | Zhao et al52 | GEO | R | Tissue | 348 | I–IV | None | Downloaded | >150 | Univariate | 1.63 | 1.19–2.23 | |
LINC00673 | Ba et al61 | China | R | Frozen | 79 | I–IV | Median | qRT-PCR | 66 | Multivariate | 2.56 | 1.01–4.54 | |
LINC00673 | Huang et al62 | China | R | Tissue | 73 | I–IV | 2 | qRT-PCR | >40 | Multivariate | 2.38 | 1.12–5.06 | |
MALAT1 | Qi et al72 | TCGA | R | Tissue | 118 | III–IV | None | RT-qPCR | >50 | Univariate | 1.98 | 1.38–2.83 | |
MALAT1 | Li et al73 | China | R | Tissue | 78 | I–IV | None | qRT-PCR | >60 | Univariate | 2.52 | 1.35–4.68 | |
MALAT1 | Li et al74 | China | R | FFPE | 150 | I–IV | None | RT-qPCR | >150 | Univariate | 1.38 | 1.03–1.85 | |
MALAT1 | Okugawa et al43 | Japan | R | Frozen | 150 | III–IV | 0.985 | RT-qPCR | 60 | Univariate | 1.54 | 0.92–2.58 | |
MEG3 | Sun et al76 | China | R | Frozen | 72 | II–IV | Median | RT-qPCR | 48 | Univariate | 1.93 | 0.99–3.75 | |
MEG3 | Guo et al77 | China | R | Frozen | 134 | I–IV | None | qRT-PCR | >60 | Univariate | 2.00 | 0.88–4.54 | |
PANDAR | Ma et al86 | China | R | Tissue | 100 | I–IV | None | qRT-PCR | 36 | Multivariate | 3.68 | 1.13–12.06 | |
PANDAR | Liu et al87 | China | R | Tissue | 146 | I–IV | Mean | qRT-PCR | 84 | Multivariate | 3.10 | 2.70–3.54 | |
PVT1 | Kong et al89 | China | R | Tissue | 80 | I–IV | Median | qRT-PCR | 36 | Multivariate | 2.09 | 1.07–4.10 | |
PVT1 | Yuan et al90 | China | R | Tissue | 111 | I–IV | Median | qRT-PCR | 48 | Multivariate | 2.28 | 1.05–4.93 | |
Sox2ot | Zhang et al96 | China | R | Frozen | 132 | I–IV | Median | qRT-PCR | >84 | Multivariate | 2.05 | 1.28–3.30 | |
Sox2ot | Zou et al97 | China | R | Tissue | 155 | None | Median | qRT-PCR | >60 | Univariate | 3.24 | 1.24–6.43 | |
SPRY4-IT1 | Peng et al98 | China | R | Frozen | 175 | I–IV | Median | qRT-PCR | 60 | Multivariate | 0.82 | 0.31–1.57 | |
SPRY4-IT1 | Xie et al99 | China | R | Frozen | 61 | I–IV | Median | qRT-PCR | 36 | Univariate | 2.49 | 1.08–5.75 | |
UCA1 | Zheng et al101 | China | R | Frozen | 112 | I–IV | Median | RT-qPCR | 60 | Multivariate | 2.35 | 1.22–4.52 | |
UCA1 | Nasrollahzadeh-Khakiani et al102 | TCGA | R | Tissue | 188 | I–IV | Median | Downloaded | >116 | Univariate | 1.11 | 0.72–1.73 | |
UCA1 | Zuo et al103 | China | R | Frozen | 37 | I–IV | Median | qRT-PCR | 36 | Multivariate | 2.92 | 1.07–7.96 | |
UCA1 | Gu et al104 | China | R | Frozen | 62 | I–IV | None | qRT-PCR | 60 | Univariate | 1.80 | 0.95–3.38 | |
XIST | Chen et al107 | China | R | Frozen | 106 | I–IV | Median | qRT-PCR | >90 | Multivariate | 1.72 | 1.32–2.26 | |
XIST | Ma et al108 | China | R | FFPE | 98 | I–IV | None | qRT-PCR | 54 | Univariate | 2.49 | 1.40–4.42 | |
ZEB1-AS1 | Li et al109 | China | R | Tissue | 124 | I–IV | Median | qRT-PCR | 72 | Multivariate | 2.36 | 1.41–3.96 | |
ZEB1-AS1 | Zhang et al110 | China | R | Frozen | 76 | I–IV | Median | qRT-PCR | 90 | Univariate | 2.72 | 1.27–5.84 | |
KM | R | Tissue | 631 | I–IV | None | Downloaded | >150 | Univariate | 1.95 | 1.52–2.49 | |||
ZFAS1 | Zhang et al111 | China | R | Frozen | 104 | I–IV | Median | qRT-PCR | 60 | Multivariate | 2.57 | 1.25–6.84 | |
ZFAS1 | Nie et al112 | China | R | Tissue | 54 | I–IV | Median | qRT-PCR | 36 | Univariate | 2.43 | 0.96–6.17 |
Abbreviations: AFAP1-AS1, AFAP1 antisense RNA 1; ANRIL, CDKN2B antisense RNA 1; Both, frozen and formalin-fixed paraffin-embedded tissues; CASC15, cancer susceptibility 15; CCAT2, colon cancer associated transcript 2; FFPE, formalin-fixed paraffin-embedded; GAPLINC, gastric adenocarcinoma associated, positive CD44 regulator, long intergenic noncoding RNA; GEO, Gene Expression Omnibus; H19, H19, imprinted maternally expressed transcript; HOTAIR, HOX transcript antisense RNA; HOTTIP, HOXA distal transcript antisense RNA; HR (H/L), hazard ratios of high expression versus low expression of lncRNAs; HR (L/H), hazard ratios of low expression versus high expression of lncRNAs; KM, Kaplan–Meier plotter; LINC00673, long intergenic non-protein coding RNA 673; lncRNA, long noncoding RNA; MALAT1, metastasis-associated lung adenocarcinoma transcript 1; MEG3, maternally expressed 3; OS, overall survival; PANDAR, promoter of CDKN1A antisense DNA damage activated RNA; PVT1, Pvt1 oncogene; qRT-PCR, quantitative real-time polymerase chain reaction; R, retrospective; RT-qPCR, reverse transcription quantitative real-time polymerase chain reaction; Sox2ot, SOX2 overlapping transcript; SPRY4-IT1, SPRY4 intronic transcript 1; TCGA, The Cancer Genome Atlas; UCA1, urothelial cancer associated 1; XIST, X inactive specific transcript; ZEB1-AS1, ZEB1 antisense RNA 1; ZFAS1, ZNFX1 antisense RNA 1.