Table 2.

Magnetic resonance imaging (MRI) scores (Mean ± SD) for each group (control, MSC-naïve, MSC-primed)

MRI grading parameter	Two months end-point (Phase 2 carpi)			Six months end-point (Phase 1 carpi)
	Control n = 4	MSC-naïve n = 7	MSC-primed n = 7	Control n = 4	MSC-naïve n = 7	MSC-primed n = 7
Osteophyte formation	0.25 ± 0.50	0.00 ± 0.00	0.00 ± 0.00	0.00 ± 0.00	0.33 ± 0.58	0.00 ± 0.00
Synovial effusion	1.50 ± 0.58a,b	0.67 ± 0.58a,c	2.25 ± 0.50b	1.25 ± 0.50	1.33 ± 0.58	1.75 ± 0.96
Osseous edema	0.25 ± 0.50	0.33 ± 0.58	1.25 ± 1.26	0.00 ± 0.00	0.00 ± 0.00	0.25 ± 0.50
Subchondral bone damage	1.00 ± 0.00	0.33 ± 0.58	0.50 ± 0.58	0.25 ± 0.50	0.33 ± 0.58	0.75 ± 0.50

Scores are shown for each MRI grading parameter in each group at each assessed end-point (six and two months, phases 1 and 2). The number (n) of radio-carpal (RC) joints assessed in each group at each end-point is showed in the table. Higher scores mean higher severity of the MRI findings, 4 being the highest possible score for each parameter. Different letters mean statistically significant differences (p < 0.05). Note that significant differences were only found between groups for the parameter synovial effusion at two months (phase 2), but not for other parameters or between two and six months