Table 5.

Results of peak s-Tau nested cohort analysis for the employed multivariable models

Multivariable model	Estimate	95% CI	P value
Hypocapnia vs nonhypocapniaa	1.07	0.73–1.57	0.71
Hypocapnia vs normocapniaa	1.37	0.45–4.15	0.57
Hypercapnia vs nonhypercapniaa	0.68	0.42–1.10	0.12
Hypercapnia vs normocapniaa	1.00	0.38–2.64	1.00
Amplitudeb	1.04	0.91–1.20	0.53
AUC, all valuesb	1.08	0.83–1.42	0.56
AUC, first four valuesb	0.94	0.76–1.17	0.59
TTMH Mild hypercapnia vs normocapniaa	0.75	0.43–1.28	0.29

s-Tau serum Tau, CI confidence interval, AUC area under curve, TTMH therapeutic targeted mild hypercapnia

^aFor analyses of categorical data, estimate indicates how many times higher s-Tau is compared to reference group

^bFor analyses of continuous data, estimate indicates how much higher s-Tau is per 1 kPa arterial carbon dioxide pressure increase