Table 2.
Top-ranked ICD-9 diagnoses differentially associated with KS vs. GUD / OTH / ALP
| ICD-9 code | Condition | frequency in kidney stones (KS) | other genitourinary diseases (GUD) | other conditions (OTH) | acute localized pain (ALP) | |||
|---|---|---|---|---|---|---|---|---|
| frequency | p-value* | frequency | p-value* | frequency | p-value* | |||
| 401 | Essential hypertension | 45.6% (99) | 35.4% (5101) | 0.02 | 48.5% (11447) | 0.63 | 37.6% (2797) | 0.0224 |
| 276 | Disorders of fluid, electrolyte, and acid-base balance | 43.8% (95) | 45.6% (6565) | 0.78 | 18.3% (4375) | < 0.0001 | 27.9% (2047) | < 0.0001 |
| 38 | Septicaemia | 41.5% (90) | 23.4% (3361) | < 0.0001 | 5.4% (1297) | < 0.0001 | 16.3% (1216) | < 0.0001 |
| 995 | Certain adverse effects | 39.6% (86) | 21.4% (3078) | < 0.0001 | 4.8% (1159) | < 0.0001 | 13.2% (983) | < 0.0001 |
| 785 | Symptoms involving cardiovascular system | 24.9% (54) | 18.5% (2664) | 0.09 | 5.7% (1353) | < 0.0001 | 11.1% (827) | < 0.0001 |
| 428 | Heart failure | 24.9% (54) | 38.3% (5508) | 0.00 | 16.2% (3867) | 0.002 | 29.3% (2185) | 0.1945 |
| 41 | Other bacteria infections | 21.2% (46) | 16.3% (2350) | 0.14 | 3.1% (752) | < 0.0001 | 7.5% (559) | < 0.0001 |
| 287 | Purpura and other hemorrhagic conditions | 12.9% (28) | 11.7% (1680) | 0.76 | 5.1% (1211) | < 0.0001 | 7.9% (589) | 0.0293 |
| 790 | Nonspecific findings on examination of blood | 12.0% (26) | 9.8% (1413) | 0.54 | 5.2% (1243) | < 0.0001 | 6.0% (449) | 0.0019 |
| 403 | Hypertensive renal disease | 11.1% (24) | 27.0% (3892) | < 0.0001 | 1.2% (278) | < 0.0001 | 10.8% (805) | 0.9642 |
| 278 | Obesity and other hyperalimentation | 10.1% (22) | 6.0% (863) | 0.08 | 4.7% (1121) | 0.001 | 4.2% (315) | 0.0003 |
| 311 | Depressive disorder, not elsewhere classified | 10.1% (22) | 7.7% (1104) | 0.77 | 5.9% (1403) | 0.01 | 4.7% (351) | 0.0015 |
| 300 | Neurotic disorders | 9.2% (20) | 5.68% (817) | 0.08 | 5.71% (1366) | 0.03 | 4.0% (295) | 0.0003 |
| 327 | Sleep disorders | 9.2% (20) | 5.4% (778) | 0.09 | 3.5% (843) | < 0.0001 | 2.9% (212) | < 0.0001 |
| 112 | Candidiasis | 8.8% (19) | 4.3% (619) | 0.02 | 2.0% (479) | < 0.0001 | 4.0% (298) | 0.0023 |
| 416 | Chronic pulmonary heart disease | 7.8% (17) | 6.9% (989) | 0.77 | 3.4% (809) | 0.001 | 4.3% (317) | 0.0365 |
| 799 | Decreased libido and other ill-defined conditions | 7.4% (16) | 4.7% (668) | 0.19 | 2.4% (569) | < 0.0001 | 2.5% (186) | < 0.0001 |
| 788 | Symptoms involving urinary system | 7.4% (16) | 5.7% (820) | 0.77 | 3.0% (712) | 0.001 | 3.1% (229) | 0.0019 |
| 288 | Diseases of white blood cells | 6.0% (13) | 4.7% (674) | 0.77 | 2.6% (629) | 0.001 | 2.0% (148) | 0.0004 |
| 574 | Cholelithiasis | 5.5% (12) | 2.9% (419) | 0.11 | 1.6% (392) | < 0.0001 | 3.1% (230) | 0.0558 |
| 570 | Acute and subacute necrosis of liver | 4.1% (9) | 5.0% (717) | 0.76 | 0.8% (184) | < 0.0001 | 3.1% (228) | 0.4404 |
| 345 | Epilepsy | 3.7% (8) | 3.4% (491) | 0.87 | 2.9% (688) | 0.48 | 1.5% (111) | 0.0345 |
| 346 | Migraine | 2.8% (6) | 0.79% (113) | 0.02 | 1.32% (316) | 0.11 | 0.8% (57) | 0.0052 |
* first 25 ICD-9 codes or those with a false discovery rate-adjusted p-value< 0.05 are shown