Table 3.
Top-ranked laboratory tests differentially associated with KS vs. GUD / OTH / ALP
| Lab test item | kidney stones (KS) | other genitourinary diseases (GUD) | other conditions (OTH) | acute localized pain (ALP) | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| mean | Median (IQR) | Mean | Median (IQR) | p-value* | Mean | Median (IQR) | p-value* | Mean | Median (IQR) | p-value* | |
| Urine | |||||||||||
| White Blood Cells (WBC) (#/hpf) | 5.5 | 4.9 (3.1, 6.2) | 3.0 | 2.2 (1.7, 2.9) | < 0.0001 | 1.5 | 1.5 (1.5, 1.5) | < 0.0001 | 2.1 | 1.2 (1.2, 2.2) | < 0.0001 |
| Red Blood Cells (RBC) (#hpf) | 5.8 | 4.5 (3.3, 6.2) | 3.4 | 2.4 (1.7, 3.3) | < 0.0001 | 1.9 | 1.4 (1.4, 1.4) | < 0.0001 | 2.7 | 1.4 (1.4, 2.4) | < 0.0001 |
| Creatinine (mg/dL) | 80.0 | 73.0 (73.0, 73.0) | 84.7 | 78.0 (70.5, 86.0) | 0.03 | 77.9 | 75.0 (75.0, 75.0) | 0.03 | 81.9 | 75.0 (75.0, 78.0) | 0.03 |
| Protein (mg/dL) | 4.0 | 4.0 (3.4, 4.2) | 3.9 | 3.8 (3.4, 4.0) | 0.03 | 3.5 | 3.4 (3.4, 3.4) | < 0.0001 | 3.7 | 3.4 (3.4, 3.8) | < 0.0001 |
| pH | 6.0 | 6.0 (5.5, 6.5) | 5.8 | 5.7 (5.2, 6.2) | < 0.0001 | 6.0 | 6.0 (5.5, 6.5) | 0.86 | 6.0 | 6.0 (5.4, 6.5) | 0.17 |
| Blood | |||||||||||
| Bands | 4.5 | 3.0 (2.0, 3.8) | 2.5 | 1.3 (1.0, 1.9) | < 0.0001 | 1.5 | 0.8 (0.8, 0.8) | < 0.0001 | 2.3 | 0.8 (0.5, 2.0) | < 0.0001 |
| Potassium (mEq/L) | 4.1 | 4.0 (3.9, 4.1) | 4.3 | 4.2 (4.0, 4.4) | < 0.0001 | 4.1 | 4.1 (3.9, 4.2) | 0.09 | 4.2 | 4.1 (3.9, 4.3) | < 0.0001 |
| Lipase (U/L) | 67.1 | 28.0 (26.0, 33.0) | 62.6 | 35.0 (30.0, 42.0) | 0.03 | 44.9 | 31.0 (31.0, 31.0) | 0.05 | 65.4 | 31.0 (27.0, 45.0) | 0.03 |
| Magnesium (mEq/L) | 2.0 | 2.0 (1.8, 2.1) | 2.1 | 2.0 (1.9, 2.2) | < 0.0001 | 2.0 | 2.0 (1.9, 2.1) | 0.03 | 2.0 | 2.0 (1.9, 2.1) | 0.01 |
| Glucose (mg/dl) | 146.0 | 137.3 (137.3, 137.3) | 143.6 | 134.0 (127.2, 141.0) | 0.03 | 139.5 | 133.3 (127.6, 139.7) | 0.03 | 141.0 | 133.3 (124.2, 145.3) | 0.03 |
| Creatine Kinase, MB Isoenzyme (ng/mL) | 8.5 | 4.4 (4.0, 5.0) | 0.0 | 5 (4.0, 6.8) | 0.03 | 11.5 | 5.0 (5.0, 5.0) | 0.32 | 11.9 | 5 (4.7, 6) | 0.03 |
| Red Cell Distribution Width (RDW) (%) | 14.9 | 14.5 (13.7, 15.7) | 15.7 | 15.3 (14.2, 16.7) | < 0.0001 | 14.5 | 14.1 (13.4, 15.2) | 0.001 | 15.3 | 15.0 (13.92, 16.3) | 0.005 |
| Total CO2 (mEq/L) | 24.0 | 24.0 (22.0, 25.5) | 24.8 | 24.8 (22.7, 26.9) | 0.03 | 25.9 | 25.8 (24.7, 27.0) | < 0.0001 | 25.7 | 25.8 (23.8, 27.4) | < 0.0001 |
| Red Blood Cells (cells/mcL) | 3.7 | 3.6 (3.3, 4.0) | 3.5 | 3.4 (3.2, 3.8) | < 0.0001 | 3.7 | 3.7 (3.3, 4.1) | 0.09 | 3.6 | 3.5 (3.3, 3.8) | 0.01 |
| Chloride (mEq/L) | 102.6 | 102.4 (101.3, 103.7) | 101.9 | 102.0 (100.5, 103.3) | 0.001 | 101.9 | 102.0 (100.5, 103.0) | < 0.0001 | 101.8 | 101.9 (100.7, 103.0) | < 0.0001 |
| Urea Nitrogen (mg/dL) | 25.7 | 20.8 (14.1, 30.7) | 34.5 | 29.5 (19.5, 44.4) | < 0.0001 | 17.8 | 15.8 (12.0, 21.0) | < 0.0001 | 25.7 | 20.1 (13.8, 32.3) | 0.95 |
| Creatinine (mg/dL) | 1.4 | 1.1 (0.8, 1.6) | 1.9 | 1.4 (1.0, 2.1) | 0.003 | 0.9 | 0.8 (0.7, 1.0) | < 0.0001 | 1.3 | 0.9 (0.7, 1.4) | 0.80 |
| Albumin (g/dL) | 3.3 | 3.2 (2.9, 3.6) | 3.1 | 3.1 (2.8, 3.5) | 0.002 | 3.5 | 3.5 (3.3, 3.7) | < 0.0001 | 3.2 | 3.3 (2.8, 2.6) | 0.31 |
| Phosphate (mg/dL) | 3.3 | 3.2 (2.8, 3.7) | 3.7 | 3.5 (3.1, 4.1) | < 0.0001 | 3.3 | 3.3 (2.9, 3.6) | 0.60 | 3.5 | 3.4 (3.0, 3.9) | < 0.0001 |
| Oxygen Saturation (mm Hg) | 90.1 | 92.0 (92.0, 92.0) | 90.3 | 92.1 (90.4, 93.8) | 0.78 | 93.4 | 95.3 (95.3, 95.3) | < 0.0001 | 91.5 | 95.0 (90.3, 95.6) | 0.02 |
| Base Excess (mEq) | −1.6 | −1.4 (−2.7, −0.3) | −1.0 | −0.6 (−2.5, 0.9) | 0.15 | 0.1 | 0.1 (−0.6, 1.0) | < 0.0001 | −0.2 | 0.1 (−1.6, 1.4) | < 0.0001 |
| pH | 7.4 | 7.4 (7.4, 7.4) | 7.4 | 7.4 (0.3, 7.4) | 0.44 | 7.4 | 7.4 (7.4, 7.4) | < 0.0001 | 7.4 | 7.4 (7.3, 7.4) | 0.001 |
| pO2 (kPa) | 4.8 | 4.8 (4.6, 4.9) | 4.8 | 4.8 (4.6, 5.0) | 0.79 | 5.1 | 5.1 (4.9, 5.3) | < 0.0001 | 4.9 | 4.9 (4.7, 5.1) | 0.001 |
| Bicarbonate (mEq/L) | 24.6 | 24.8 (22.6, 26.5) | 24.7 | 24.8 (22.5, 26.9) | 0.78 | 25.8 | 25.8 (24.2, 27.4) | < 0.0001 | 25.5 | 25.5 (23.6, 27.2) | 0.001 |
| Lactate Dehydrogenase (LD) (IU/L) | 291.9 | 237.3 (230.9, 250.0) | 399.4 | 268.0 (230.3, 320.0) | 0.08 | 272.4 | 235.7 (235.7, 235.7) | 0.03 | 330.4 | 235.7 (226, 301) | 0.29 |
* first 25 lab items or those with a false discovery rate-adjusted p-value< 0.1 are shown