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. Author manuscript; available in PMC: 2019 Sep 1.
Published in final edited form as: Reproduction. 2018 Jun 7;156(3):R83–R99. doi: 10.1530/REP-18-0127

Figure 2.

Figure 2

Receptors for KNDy peptides in GnRH and kisspeptin neurons. Top four panels depict dual ICC for NK3R (red in A, green in C) and KOR (red in B and D) in GnRH neurons (green in A and B) and kisspeptin neurons (red in C, green in D). Arrows identify dual labeled cells, arrowheads indicate single labeled KOR neurons. Bottom panels present the mean (± SEM) percentage of GnRH and kisspeptin cells in the POA and MBH (KNDy cells for latter) containing each receptor. Note no GnRH cells contained NK3R. NA: Not analyzed. Photomicrographs in Panels A and C reprinted from Amstalden et al., 2010 and Ahn et al., J Neuroendocrinol 27: 100–110, 2015, respectively with permission from the British Society for Neuroendocrinology. Photomicrographs in panels B and D reprinted from Weems et al. 2016, with permission from the Endocrine Society. Bar graphs in bottom panel are based on data from these three references (NK3R and KOR) and from Smith et al, 2011 (Kiss1r).