Table 2.
Unadjusted odds ratios (OR), adjusted odds ratios, and 95% confidence intervals (CI) for associations between CCL2 at baseline and knee OA outcomes at follow-up
| Knee OA Outcomes |
CCL2 (n /% #) | Unadjusted OR (95% CI) |
Adjusted OR*(95% CI) |
|---|---|---|---|
|
| |||
| Knee rOA | Log (CCL2) | 1.52 (0.94, 2.47) | 1.72 (1.04, 2.83) |
|
| |||
| Tertile 1 (20/36.4) | reference | reference | |
| Tertile 2 (24/44.4) | 1.42 (0.70, 2.89) | 2.18 (0.99, 4.79) | |
| Tertile 3 (30/53.6) | 2.37** (1.17,4.80) | 3.15** (1.38, 7.19) | |
|
| |||
| Knee rOA Progression | Log (CCL2) | 1.40 (0.89, 2.19) | 1.40 (0.86, 2.28) |
|
| |||
| Tertile 1 (21/40.4) | reference | reference | |
| Tertile 2 (26/49.1) | 1.28 (0.63, 2.58) | 1.65 (0.77, 3.57) | |
| Tertile 3 (34/61.8) | 2.05** (1.04, 4.06) | 2.23** (1.03, 4.87) | |
|
| |||
| Knee Osteophytes Medial | Log (CCL2) | 0.87 (0.55, 1.37) | 0.89 (0.54, 1.48) |
|
| |||
| Tertile 1 (29/65.9) | reference | reference | |
| Tertile 2 (28/56.0) | 0.76 (0.36, 1.62) | 1.11 (0.45, 2.75) | |
| Tertile 3 (35/68.6) | 1.09 (0.52, 2.29) | 1.30 (0.53, 3.18) | |
|
| |||
| Knee Osteophytes Progression Medial | Log (CCL2) | 1.06 (0.67, 1.68) | 1.11 (0.65, 1.89) |
|
| |||
| Tertile 1 (13/30.2) | reference | reference | |
| Tertile 2 (20/40.0) | 1.20 (0.54, 2.67) | 1.72 (0.67, 4.40) | |
| Tertile 3 (21/41.2) | 1.50 (0.67, 3.37) | 1.84 (0.69, 4.86) | |
|
| |||
| Knee JSN Medial | Log (CCL2) | 1.52 (0.95, 2.41) | 1.54 (0.93, 2.54) |
|
| |||
| Tertile 1 (18/40.9) | reference | reference | |
| Tertile 2 (24/48.0) | 1.39 (0.67, 2.88) | 1.70 (0.78, 3.70) | |
| Tertile 3 (30/60.0) | 2.60** (1.24, 5.43) | 2.83** (1.26, 6.35) | |
|
| |||
| Knee JSN Progression Medial | Log (CCL2) | 1.37 (0.85, 2.22) | 1.38 (0.83, 2.27) |
|
| |||
| Tertile 1 (12/27.9) | reference | reference | |
| Tertile 2 (17/34.0) | 1.33 (0.58, 3.09) | 1.85 (0.78, 4.40) | |
| Tertile 3 (24/48.0) | 2.15 (0.97, 4.78) | 2.43** (1.05, 5.62) | |
|
| |||
| Knee SxOA | Log (CCL2) | 1.13 (0.68, 1.88) | 1.09 (0.62, 1.92) |
|
| |||
| Tertile 1 (17/30.9) | reference | reference | |
| Tertile 2 (19/35.2) | 1.21 (0.55, 2.70) | 1.47 (0.61, 3.56) | |
| Tertile 3 (23/41.1) | 1.56 (0.71, 3.40) | 1.57 (0.64, 3.85) | |
*
Adjusted ORs from logistic models adjusted for continuous age and BMI, and categorical race and gender.
#
Frequency and percentage of each CCL2 tertile for each knee OA outcome. CCL2 range in each tertile: tertile 1 (21.04, 221.30), tertile 2 (223.54, 358.10), tertile 3 (373.82, 2192.27) (Supplementary Fig S1)
**
Statistically significant linear trend tests showing increasing effect on the outcome across the tertiles of CCL2.