Table 3.
Univariate and multivariate analyses of prognostic factors of cancer survival by sarcoma type
| All sarcomas | Osteosarcoma | Chondrosarcoma | Ewing sarcoma | |||||
|---|---|---|---|---|---|---|---|---|
| Univariate | Multivariate | Univariate | Multivariate | Univariate | Multivariate | Univariate | Multivariate | |
| HR (95% CI) | HR (95% CI) | HR (95% CI) | HR (95% CI) | HR (95% CI) | HR (95% CI) | HR (95% CI) | HR (95% CI) | |
| Age at diagnosis | ||||||||
| AYA | Reference | Reference | Reference | Reference | Reference | Reference | Reference | Reference |
| Child | 1.04 (0.79–1.36) | 0.83 (0.59–1.18) | 1.02 (0.73–1.42) | 1.00 (0.70–1.43) | 0.57 (0.33–1.00) | 0.35 (0.15–0.83) | ||
| Adult | 1.14 (0.92–1.43) | 1.61 (1.16–2.24) | 1.99 (1.42–2.78) | 1.58 (1.11–2.24) | 1.82 (0.66–5.02) | 1.77 (0.63–4.94) | 1.92 (0.98–3.74) | 1.97 (0.69–5.65) |
| Elderly | 1.99 (1.61–2.46) | 3.74 (2.66–5.28) | 4.35 (3.14–6.02) | 3.26 (2.29–4.64) | 7.38 (2.91–18.75) | 6.13 (2.38–15.75) | NA | NA |
| Sex | ||||||||
| Male | Reference | Reference | Reference | Reference | Reference | Reference | Reference | Reference |
| Female | 0.93 (0.79–1.10) | 0.85 (0.68–1.06) | 1.01 (0.80–1.29) | 0.96 (0.75–1.23) | 1.07 (0.64–1.78) | 1.20 (0.70–2.06) | 0.96 (0.60–1.55) | 1.08 (0.53–2.19) |
| Histologic grade | ||||||||
| Low | Reference | Reference | Reference | Reference | ||||
| High | 6.63 (4.71–9.34) | 3.77 (1.93–7.37) | 4.73 (2.75–8.14) | 3.27 (1.84–5.83) | ||||
| Tumor size | ||||||||
| ≤8 cm | Reference | Reference | Reference | Reference | Reference | Reference | Reference | Reference |
| > 8 cm and ≤ 16 cm | 1.84 (1.53–2.21) | 1.26 (0.99–1.62) | 1.74 (1.32–2.30) | 1.63 (1.23–2.16) | 2.79 (1.55–5.02) | 2.03 (1.12–3.70) | 0.86 (0.51–1.44) | 0.55 (0.25–1.23) |
| > 16 cm | 2.92 (2.21–3.87) | 2.20 (1.52–3.19) | 2.65 (1.74–4.030) | 2.84 (1.86–4.35) | 4.81 (2.30–10.07) | 3.06 (1.40–6.68) | 3.00 (1.41–6.37) | 2.39 (0.87–6.57) |
| Tumor location | ||||||||
| Upper extremity | Reference | Reference | Reference | Reference | Reference | Reference | Reference | Reference |
| Lower extremity | 1.64 (1.14–2.37) | 1.41 (0.94–2.12) | 1.30 (0.79–2.14) | 1.19 (0.72–1.98) | 2.65 (0.78–9.04) | 2.30 (0.66–8.03) | 1.37 (0.52–3.61) | 1.63 (0.51–5.22) |
| Trunk | 2.48 (1.72–3.59) | 1.43 (0.91–2.23) | 4.43 (2.63–7.46) | 2.64 (1.53–4.56) | 4.40 (1.36–14.25) | 3.62 (1.08–12.15) | 1.01 (0.40–2.55) | 1.19 (0.36–3.91) |
| Head and neck | 1.93 (0.75–4.95) | 0.82 (0.19–3.51) | 1.35 (0.40–4.60) | 1.73 (0.50–6.04) | 1.78 (0.21–15.34) | 5.16 (0.53–50.02) | ||
| Multiple disease | 5.99 (3.68–9.74) | 2.60 (1.17–5.78) | ||||||
| Limb salvage | ||||||||
| Salvaged | Reference | Reference | Reference | Reference | Reference | Reference | ||
| Amputated | 2.15 (1.72–2.70) | 2.98 (2.28–3.89) | 2.47 (1.83–3.33) | 2.80 (2.05–3.83) | 1.56 (0.62–3.96) | 2.01 (0.80–5.07) | ||
| Surgical margin | ||||||||
| Negative (wide or marginal) | Reference | Reference | Reference | Reference | Reference | Reference | ||
| Positive (intralesional) | 1.14 (0.81–1.60) | 1.78 (1.21–2.62) | 1.26 (0.52–3.07) | 0.68 (0.26–1.76) | 3.67 (1.60–8.40) | 5.28 (1.90–14.62) | ||
AYA adolescent and young adult, HR Hazard ratio, CI confidence interval