TABLE 3:

Univariate and multivariate Cox proportional hazards regression, overall and with a 2-year survival cutoff

	Overall				Data Censored at 2 Yrs
	Univariate		Multivariate		Univariate		Multivariate
Variable	HR (95% CI)	p Value	HR (95% CI)	p Value	HR (95% CI)	p Value	HR (95% CI)	p Value
age (per yr)	1.0005 (0.97–1.03)	0.973			1.00 (0.97–1.02)	0.80
sex		0.18				0.18
F	1*				1*
M	1.47 (0.83–2.63)				1.55 (0.84–2.86)
ipilimumab		0.04				0.007
no	1*		1*		1*		1*
yes	0.55 (0.31–0.99)		0.61 (0.33–1.10)	0.102	0.43 (0.22–0.82)		0.48 (0.24–0.93)	0.03
WBRT		0.14				0.34
no	1*				1*
yes	1.55 (0.87–2.76)				1.34 (0.74–2.40)
ECOG PS		<0.01				<0.0001
2	1*				1*
1	0.26 (0.11–0.65)				0.26 (0.11–0.65)
0	0.09 (0.04–0.24)				0.09 (0.04–0.24)
DS-GPA score		<0.01
0–1	1*		1*		1*		1*
2	0.26 (0.12–0.55)		0.25 (0.11–0.54)	<0.001	0.26 (0.12–0.56)		0.25 (0.11–0.54)	<0.001
3	0.14 (0.06–0.35)		0.15 (0.06–0.36)	<0.001	0.14 (0.06–0.34)		0.14 (0.05–0.35)	<0.001
4	0.07 (0.02–0.21)		0.07 (0.03–0.21)	<0.001	0.08 (0.03–0.23)		0.09 (0.03–0.25)	<0.001
craniotomy		0.85				0.55
no	1*				1*
yes	0.95 (0.53–1.70)				0.83 (0.45–1.54)
yr of diagnosis	0.93 (0.78–1.11)	0.44
yr of SRS	0.95 (0.79–1.14)	0.61

^*Reference value.