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. Author manuscript; available in PMC: 2019 Sep 1.
Published in final edited form as: J Hepatol. 2018 Apr 27;69(3):687–696. doi: 10.1016/j.jhep.2018.04.004

Fig. 1. Low liver BHB in humans with alcoholic hepatitis and a combination of etomoxir and ethanol induces liver injury in mice.

Fig. 1

(A) BHB levels from normal and alcoholic hepatitis human livers. Data are shown as means +/− SEM. Control, n = 15; AH, n=10. (B–H) Mice were injected i.p. with etomoxir (20mg/kg) or saline. 30 minutes later they were gavaged with PBS or ethanol (6g/kg). Plasma and livers were harvested 16 hours after ethanol gavage. (B) Representative liver histology. (C) Statistical analysis of steatosis scores. U.D. Undetectable. (D) Statistical analysis of liver TG levels. (E) Plasma ALT. (F) Statistical results of neutrophil (CD45+CD11b+Ly6G+) numbers in the liver by flow cytometry. (G) Representative images of Ly6B+ neutrophils in the liver. (H) Statistical analysis of Ly6B+ neutrophils in the liver by immunohistochemistry. C–H, n=6–8 per group. (I) Mice were injected i.p. with etomoxir (20mg/kg) or saline. 30 minutes later they were gavaged with PBS or ethanol (6g/kg). Livers were harvested 6 hours after ethanol gavage and the liver BHB levels were detected (n=7~8 per group). Data were analyzed with nonparametric Wilcoxon rank-sum tests.* P<0.05; ** P<0.01; ***P<0.001.