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. 2018 Jul 3;6(8):1612–1617. doi: 10.1002/ccr3.1693

Figure 2.

Figure 2

Conservation analysis of FBN2 p.Cys1393. A, Phylogenetic comparison of FBN2 across species. B, Phylogenetic comparison of human fibrillin‐1, 2, and 3. C, The putative structural domains. The p.Cys1393Gly mutation identified was located in cbEGF domain 18. D, Multiple sequence alignment of cbEGF domain 18‐19 of fibrillin‐2. Disulfide bonds are shown indicated by black lines (SS). Location of Cys 1393 is shown by the red arrow. E, Modeled structure of cbEGF domain 18 and 19 of fibrillin‐2. The disulfide bonds are shown by green lines