| 1. Hyper-LDL cholesterolemia: LDL-C level of ≥ 140 mg/dL when untreated |
| (If total cholesterol level is ≥ 220 mg/dL, measure the LDL-C level) |
| 2. Family history of FH or premature CAD (blood relative closer than the two parents) |
|
| • Excluding secondary hyperlipidemia, if two items are satisfied, FH is diagnosed. |
| • During the growth phase, there are fluctuations in LDL-C; therefore, careful observation is required. |
| • In pediatric cases, there are few clinical symptoms such as xanthomatosis; therefore, it is important to investigate the family history for FH. Use the family survey results of those beyond the parents as a reference if necessary. |
| • Early CAD is defined as CAD with an onset at < 55 years of age for males and < 65 years of age in females, respectively |
| • If xanthoma is present, LDL-C is suspected to be extremely high (homozygote). |
