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. 2018 Aug 13;9:883. doi: 10.3389/fphar.2018.00883

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Copyright © 2018 Gharbia, Balta, Herman, Rosu, Váradi, Bácskay, Vecsernyés, Gyöngyösi, Fenyvesi, Voicu, Stan, Cristian, Dinischiotu and Hermenean.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of Sy-HPBCD and Sy-RAMEB complexes on collagen over-production. (A) RT-PCR analysis of Col 1 gene level. ^∗∗∗p < 0.001 compared to control; ^###p < 0.001 compared to CCl₄ group; ⁺⁺⁺p < 0.001 compared to CCl₄ control group; ˆp < 0.05 compared to CCl₄/Sy group; ˆˆˆp < 0.001 compared to CCl₄/Sy group. (B) Immunohistochemical expression of Col 1 in experimental livers. (a) Control group, (b) CCl₄-treated group, (c) CCl₄-control group, (d) CCl₄ and Sy-RAMEB co-treated group, (e) CCl₄ and Sy-HPBCD co-treated group, (f) CCl₄ and free Sy co-treated group. (C) Collagen deposition in experimental livers by electron microscopy. (a) Control group, (b) CCl₄-treated group, (c) CCl₄-control group, (d) CCl₄ and Sy-RAMEB co-treated group, (e) CCl₄ and Sy-HPBCD co-treated group, (f) CCl₄ and free Sy co-treated group; Collagen fibers (arrow); N, nucleus.