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Complexation efficiency (CE), stability constant of 1:1 complex of silymarin formed with HPBCD and RAMEB (K1:1) and improvement of dissolution calculated from the phase-solubility curves of silymarin complexed with HPBCD and RAMEB.
| CE | K1:1 | S0 (mM) | Sy solubility enhancement | |
|---|---|---|---|---|
| HPBCD | 0.42 | 890 | 0.467 | 27 |
| RAMEB | 0.49 | 1060 | 0.467 | 29 |
