Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Aug 13;9:823. doi: 10.3389/fphar.2018.00823

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2018 Fang, Zhong, Song, Deng, Yang, Xiong, Zeng and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Urinary trypsin inhibitor enhanced expression of tight junctional proteins in CLP group. Confocal images showing occludin (A), claudin-5 (B), and ZO-1 (C) expression in rat lungs. Occludin, claudin-5, and ZO-1 expression (red) was intensely labeled in CD31 positive PMVECs (green) of sham group lung tissues (Aa1–3,Ba1–3,Ca1–3) but was hardly detected in CLP group (Ab1–3,Bb1–3,Cb1–3). The expression was markedly increased in CLP rats treated with UTI (Ac1–3,Bc1–3,Cc1–3). Western blot showing expression level of occludin (D), claudin-5 (E), and ZO-1 (F) that was significantly decreased in CLP when compared with the control (p = 0.001, 0.000, and 0.001, respectively); it was significantly augmented when pretreated with UTI (p = 0.018, 0.021, and 0.026, respectively). Scale bars: 50 μm, DAPI-blue. All values represent mean ± SD in triplicate; ^∗represent significant differences, p < 0.05.