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. 2018 Aug 13;9:823. doi: 10.3389/fphar.2018.00823

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Copyright © 2018 Fang, Zhong, Song, Deng, Yang, Xiong, Zeng and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Protein expression of p-P38/P38 MAPK, p-IκB/i-κb, p-JNK/JNK, and p-ERK/ERK was decreased in LPS-treated PMVECs following UTI pretreatment. p-P38/P38 MAPK, p-IκB/i-κb, p-JNK/JNK, and p-ERK/ERK expression in PMVECs was increased significantly at 30 min (p = 0.001, 0,002, 0.000, and 0.013, respectively) and 60 min (p = 0.001, 0.000, 0.001, and 0.0012, respectively) following treatment with LPS when compared with the control group; it was markedly decreased when given UTI (p = 0.015, 0.012, 0.033, and 0.019, respectively at 30 min; p = 0.022, 0.009, 0.018, and 0.015, respectively at 60 min). Significant differences in protein levels are expressed as ^∗p < 0.05. The values represent the mean ± SD in triplicate.