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Proteolytic molecules. Graphs show 20S proteasome activity (A) and atrophic gene MuRF1 (B) and MAFbx (C) mRNA levels in the groups of Fetal Start (n = 6/7), Fetal End (n = 6/7), MV (n = 9/10), and MV + VARA (n = 6). Values are Mean (SD) for 20S proteasome activity or Median (25th and 75th centile) for mRNA level data, expressed as fold-change relative to Fetal Start group. ∗indicates p < 0.05. MV, mechanical ventilation; VARA, vitamin A and all-trans retinoic acid.
