Table 3.
Postnatal respiratory variables.
| Variable | Time (h) | MV | MV + VARA | p-value |
| FiO2 (%) | ||||
| 24 | 27 (10) | 37 (22) | 0.152 | |
| 48 | 28 (9) | 30 (7) | 0.271 | |
| 72 | 28 (10) | 32 (15) | 0.938 | |
| PaO2 (mm Hg) | ||||
| 24 | 73 (11) | 91 (25)∗ | 0.042 | |
| 48 | 84 (12) | 84 (11) | 0.699 | |
| 72 | 78 (11) | 69 (9) | 0.083 | |
| O2 Saturation (%) | ||||
| 24 | 95 (2) | 95 (3) | 0.855 | |
| 48 | 96 (2) | 95 (2) | 0.519 | |
| 72 | 95 (3) | 94 (2) | 0.250 | |
| PIP (cmH2O) | ||||
| 24 | 16 (3) | 19 (5) | 0.212 | |
| 48 | 19 (3) | 21 (4) | 0.206 | |
| 72 | 19 (3) | 21 (3) | 0.189 | |
| MAP (cmH2O) | ||||
| 24 | 11 (1) | 13 (1)∗ | 0.025 | |
| 48 | 12 (1) | 12 (2) | 0.981 | |
| 72 | 12 (1) | 12 (1) | 0.895 | |
| pH | ||||
| 24 | 7.33 (0.07) | 7.32 (0.04) | 0.733 | |
| 48 | 7.32 (0.04) | 7.29 (0.06) | 0.171 | |
| 72 | 7.34 (0.08) | 7.38 (0.09) | 0.326 | |
| PaCO2 (mm Hg) | ||||
| 24 | 46 (6) | 54 (13) | 0.124 | |
| 48 | 51 (8) | 55 (8) | 0.438 | |
| 72 | 53 (6) | 52 (14) | 0.179 | |
| PaO2/FiO2 | ||||
| 24 | 299 (80) | 281 (139) | 0.793 | |
| 48 | 348 (139) | 339 (114) | 0.437 | |
| 72 | 296 (96) | 265 (161) | 0.519 | |
| OI | ||||
| 24 | 2.46 (1.10) | 3.18 (2.06) | 0.313 | |
| 48 | 2.45 (1.30) | 3.02 (0.78) | 0.364 | |
| 72 | 2.79 (1.67) | 3.52 (3.48) | 0.606 | |
MV, mechanical ventilation; VARA, vitamin A all-trans-retinoic acid; FiO2, fractional inspired oxygen; PaO2, arterial partial pressure of oxygen; PIP, peak inspiratory pressure; MAP, mean airway pressure; PaCO2, arterial partial pressure of carbon dioxide; OI, oxygenation Index [FiO2 × 100 × MAP/(PaO2 × 1.36)]. Values are mean (SD) or median (IQR) for parametric and non-parametric variables, respectively.