Table 3.
Effect of 1 and 3 on selected types of VGCCs and potassium channels.
| Compound | Cav1.2a (L-type) | Cav2.1a (P/Q-type) | Cav3.1a (T-type) | BKb channel | Kv1.1b | Kv2.1b | Kv3.1b |
|---|---|---|---|---|---|---|---|
| 1 | 10.1 ± 1.2% | 1.3 ± 0.3% | 11.8 ± 2.9% | 15.5 ± 1.0% | 2.8 ± 1.1% | 1.0 ± 1.1% | 0.5 ± 0.5% |
| 3 | 13.5 ± 4.1% | 7.8 ± 1.2% | 20.4 ± 7.4% | 6.7 ± 7.7% | – | – | – |
aPeak current inhibition ratio of compounds at 10 μM; bPeak current inhibition ratio of compounds at 30 μM; “-” not tested, due to the limited amount of material. Data represent the mean ± SEM of 3 or 4 cells.