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. 2018 Aug 13;9:889. doi: 10.3389/fphar.2018.00889

FIGURE 3.

FIGURE 3

CBD significantly inhibits total EMV, exosome and MV release from PC3 cells. Inhibitory effects of CBD alone and in combination with Cl-amidine on extracellular vesicle release from PC3 cancer cells are presented as histograms which are based on size exclusion analysis by Nanosight Tracking Analysis (NTA). EMVs represent all vesicles 0–900 nm (A); exosomes are vesicles <100 nm (B); and microvesicles (MV) are 100–900 nm (C). The experiments were repeated three times and the data presented are mean ± SEM of the results (∗p ≤ 0.05; ∗∗p ≤ 0.01; ∗∗∗p ≤ 0.001; ∗∗∗∗p ≤ 0.0001 versus Control; Differences between CBD and Cl-amidine treatment group is further indicated as #p ≤ 0.05; ##p ≤ 0.01; ###p ≤ 0.001; ####p ≤ 0.0001).