Table 2.

Jill Buyon MD, personal communication, 2017

Assumptions	Recurrence rate of CHB (whether previous child had CHB or rash) is ∼18% Clinically meaningful outcome would be at least 50% reduction in recurrence rate
Power calculations	18% → 10% recurrence rate: 320 per group (n = 640) 18% → 5% recurrence rate: 101 per group (n = 202)