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. 2018 Aug 13;9:779. doi: 10.3389/fphar.2018.00779

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Copyright © 2018 Zhou, Wong, Yeung, Dong, Xiao, Gong, Tsim and Wong.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of DBT, SERMs, and their combinations on serum level of OCN and urinary DPD of OVX rats. Six-month-old Sprague-Dawley rats were given ovariectomy or sham operation, After 2 weeks’ recovery, OVX rats were orally administrated with vehicle, 17β-estradiol (2.0 mg/kg day), tamoxifen (1.0 mg/kg day), raloxifene (3.0 mg/kg day), DBT (3 g/kg day), DBT+Tamoxifen, and DBT+Raloxifene for 12 consecutive weeks. (A) Serum level of OCN (ng/ml). (B) Urinary DPD (nmol/mmol). Data are expressed as mean ± SEM. ^∗∗p < 0.01, ^∗∗∗p < 0.001 vs. sham; ^∧p < 0.05, ^∧∧∧p < 0.001 vs. OVX. n = 7–9.