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. 2018 Aug 13;9:779. doi: 10.3389/fphar.2018.00779

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Copyright © 2018 Zhou, Wong, Yeung, Dong, Xiao, Gong, Tsim and Wong.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of DBT, SERMs, and their combinations on mRNA expression of bone remodeling-related genes in femoral head of OVX rats. mRNA expression of bone remodeling-related genes in femoral head was determined by real-time PCR. (A) ALP mRNA expression; (B) OCN mRNA expression; (C) IL-6 mRNA expression; (D) IL-1β mRNA expression; (E) RANKL mRNA expression; (F) OPG mRNA expression; (G) OPG/RANKL ratio. Data are expressed as mean ± SEM. ^∗p < 0.05, ^∗∗p < 0.01 vs. sham; ^∧p < 0.05, ^∧∧p < 0.01 vs. OVX. n = 7–9.