. 2018 Aug 13;9:779. doi: 10.3389/fphar.2018.00779

Table 4.

Effects of DBT, tamoxifen, raloxifene, and their combinations on trabecular bone properties of OVX rats.

	Proximal tibia					Lumbar vertebra
	BS (mm²)	BV/TV (%)	Tb.N (1/mm)	Tb.TH (mm)	Tb.Sp (mm)	BS (mm²)	BV/TV (%)	Tb.N (1/mm)	Tb.TH (mm)	Tb.Sp (mm)
Sham	228.8 ± 9.4	51.7 ± 2.3	5.0 ± 0.1	0.10 ± 0.004	0.10 ± 0.01	89.9 ± 2.7	44.2 ± 1.2	4.1 ± 0.1	0.11 ± 0.001	0.14 ± 0.01
OVX	55.0 ± 7.7**	7.6 ± 1.0***	1.2 ± 0.2***	0.06 ± 0.001***	0.86 ± 0.14***	62.6 ± 5.2**	20.9 ± 1.6***	2.6 ± 0.2***	0.08 ± 0.001***	0.31 ± 0.03***
E2	155.1 ± 10.3^∧∧	25.5 ± 2.3^∧∧∧	3.4 ± 0.2^∧∧∧	0.08 ± 0.002^∧	0.21 ± 0.01^∧∧∧	90.4 ± 3.3^∧∧	35.0 ± 1.0^∧∧∧	3.7 ± 0.1^∧∧∧	0.09 ± 0.002^∧∧	0.18 ± 0.01^∧∧∧
Tamo	128.5 ± 10.7^∧∧	20.7 ± 2.1^∧∧	2.9 ± 0.2^∧∧∧	0.07 ± 0.003	0.29 ± 0.03^∧∧∧	89.7 ± 5.9^∧	36.6 ± 1.4^∧∧∧	3.7 ± 0.1^∧∧∧	0.10 ± 0.002^∧∧∧	0.18 ± 0.01^∧∧∧
Ralo	117.3 ± 6.1^∧∧	19.9 ± 1.5^∧	2.9 ± 0.1^∧∧∧	0.07 ± 0.004	0.29 ± 0.02^∧∧∧	93.0 ± 4.7^∧	37.5 ± 1.1^∧∧∧	3.7 ± 0.1^∧∧∧	0.10 ± 0.002^∧∧∧	0.17 ± 0.01^∧∧∧
DBT	110.4 ± 18.6	17.2 ± 4.7	2.5 ± 0.3^∧∧∧	0.07 ± 0.004	0.42 ± 0.06^∧∧∧	81.3 ± 4.8^∧	30.7 ± 1.9^∧∧	3.4 ± 0.1^∧∧∧	0.09 ± 0.004	0.21 ± 0.01^∧∧∧
DBT+Tamo	129.4 ± 9.7^∧∧	21.4 ± 2.5^∧∧	3.1 ± 0.2^∧∧∧	0.07 ± 0.003	0.26 ± 0.02^∧∧∧	90.8 ± 5.6^∧∧	36.1 ± 2.1^∧∧∧	3.6 ± 0.1^∧∧∧	0.01 ± 0.003^∧∧∧	0.18 ± 0.01^∧∧∧
DBT+Ralo	131.8 ± 10.1	22.4 ± 1.8^∧∧	2.9 ± 0.2^∧∧∧	0.077 ± 0.003^∧	0.27 ± 0.02^∧∧∧	81.4 ± 3.0^∧	37.1 ± 1.0^∧∧∧	3.5 ± 0.1^∧∧∧	0.105 ± 0.002^∧∧∧	0.18 ± 0.01^∧∧∧
Two-factor ANOVA p-value
Tamo	0.0010	0.0059	<0.0001	0.0364	<0.0001	0.0021	<0.0001	<0.0001	0.0364	<0.0001
DBT	0.0329	0.0871	0.0041	0.1394	0.0070	0.0774	0.0138	0.0041	0.1394	0.0070
DBT × Tamo	0.0385	0.1367	0.0296	0.2467	0.0171	0.1144	0.0070	0.0296	0.2467	0.0171
Ralo	0.0014	0.0028	<0.0001	0.0043	0.0001	0.0021	<0.0001	<0.0001	0.0043	0.0001
DBT	0.0063	0.0316	0.0038	0.0247	0.0087	0.4365	0.0030	0.0038	0.0247	0.0087
DBT × Ralo	0.0951	0.1949	0.0078	0.5882	0.0124	0.0022	0.0015	0.0078	0.5882	0.0124

^∗∗p < 0.01, ^∗∗∗p < 0.00‘ vs. sham; ^∧p < 0.05, ^∧∧p < 0.01, ^∧∧∧p < 0.001 vs. OVX. Results are expressed as mean ± SEM, n = 7–9 rats per group. BS, bone surface; Tb.N, trabecular bone number; Tb.Th, trabecular bone thickness; Tb.Sp, trabecular bone separation; Tamo, tamoxifen; Ralo, raloxifene.