Figure 1.

TCL1 interacts relevant partners. (A) TCL1 interacts with ATM and IκB and induces enhanced activation of the NF-κB signaling pathway in CLL and lymphoma. (B) HSP70 regulates TCL1 protein folding and stabilizes its expression. Following treatment with myricetin, HSP70 activity is compromised and TCL1 is ubiquitinated and degraded. (C) TCL1 interacts with the transcription factor p63 and with its promoter region by recognizing an AP1 consensus sequence. TCL1 and p63 cooperate to activate both the PI3K and the NF-κB signaling pathways.