Table 1.
Expression of different histamine receptors on various cells.
| Histamine receptors | G-proteins | Expression on various cells | Reference |
|---|---|---|---|
| H1R | Gq/11 | Human mast cells (skin, LAD2, intestinal mast cells) | (43–45) |
| Tamm–Horsfall protein 1 (THP-1) | (33, 46) | ||
| Nerve cells | (19) | ||
| T-cells | (10, 11, 19) | ||
| Airway and vascular smooth muscles | (19) | ||
| Endothelial cells | (19) | ||
| Epithelial cells | (47) | ||
| Hepatocytes | (19) | ||
| Chondrocytes | (19) | ||
| Basophils | (19) | ||
| B cells | (19) | ||
| Peripheral blood mononuclear cell (PBMC) | (45) | ||
| Eosinophils | (19) | ||
| Neutrophils | (19) | ||
| Dendritic cells | (15, 19) | ||
| Natural killer cells | (15) | ||
| SW756 cervical carcinoma cells | (44) | ||
| Conjunctival fibroblast | (48) | ||
| Macrophage | (12) | ||
| H2R | GαS | Human mast cells (skin, LAD2) | (43, 44) |
| THP-1 | (46) | ||
| T-cells | (10, 11, 49) | ||
| Conjunctival fibroblast | (48) | ||
| Eosinophils | (50) | ||
| PBMCs | (51, 52) | ||
| Airway and vascular smooth muscles | (19) | ||
| Endothelial cells | (19, 40) | ||
| Epithelial cells | (19) | ||
| Hepatocytes | (19) | ||
| Chondrocytes | (19) | ||
| Nerve cells | (19) | ||
| B cells | (19) | ||
| Monocytes | (19) | ||
| Basophils | (19) | ||
| Neutrophils | (53) | ||
| SW756 cervical carcinoma cells | (44) | ||
| H3R | Gi/o | Neuroblastoma cell line MHH-NB-11 | (45) |
| Dendritic cells | (19) | ||
| Eosinophils | (19) | ||
| Histaminergic neurons | (19) | ||
| Mast cells (LAD2) | (44) | ||
| H4R | Gi/os | Human mast cells (skin, LAD2, HMC-1, cord blood mast cells, intestinal mast cells) | (33, 43–45) |
| Bone marrow and peripheral hematopoietic cells | (19) | ||
| THP-1 | (33) | ||
| SW756 cervical carcinoma cells | (44) | ||
| Nerve cells | (40) | ||
| Conjunctival fibroblast | (48) | ||
| PBMC | (45) | ||
| T-cells | (19, 49, 54) | ||
| Natural killer cells | (15) | ||
| Basophils | (6, 55) | ||
| Eosinophils | (5, 7, 50) | ||
| Neutrophils | (19, 40) | ||
| Monocytes-derived dendritic cells | (56) | ||
| Macrophage | (40) | ||
| Myeloid cells | (57) | ||
| Dendritic cells | (15, 19) | ||