Table 2.

Results of multivariable Cox regression analysis

	Training cohort		Validation cohort		Entire cohort
	Hazard ratio	P	Hazard ratio	P	Hazard ratio	P
Immunoscore*	1·92 (1·54, 2·40)	< 0·001	1·81 (1·17, 2·79)	0·008	1·89 (1·56, 2·30)	< 0·001
Age*	1·02 (1·01, 1·04)	< 0·001	1·02 (1·00, 1·04)	0·069	1·02 (1·01, 1·03)	< 0·001
Tumour stage		< 0·001		< 0·001		< 0·001
I	1·00 (reference)		1·00 (reference)		1·00 (reference)
II	3·23 (1·24, 8·41)	0·016	2·12 (0·71, 6·34)	0·179	2·75 (1·35, 5·64)	0·006
III	7·85 (3·14, 19·62)	< 0·001	2·59 (0·88, 7·59)	0·083	5·36 (2·69, 10·67)	< 0·001
IV	22·21 (8·85, 55·73)	< 0·001	6·58 (2·25, 19·19)	0·001	14·34 (7·18, 28·64)	< 0·001
Laurén classification		0·391		0·670		0·536
Intestinal	1·00 (reference)		1·00 (reference)		1·00 (reference)
Diffuse	1·41 (0·86, 2·33)	0·177	1·09 (0·52, 2·25)	0·825	1·18 (0·78, 1·76)	0·433
Mixed	1·04 (0·75, 1·42)	0·825	1·26 (0·76, 2·10)	0·374	1·11 (0·85, 1·44)	0·458

Values in parentheses are 95 per cent confidence intervals.

^*Continuous variable.