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. 2018 Jun 12;360(14):2742–2751. doi: 10.1002/adsc.201800541

Figure 1.

Figure 1

HLADH‐catalyzed asymmetric disproportionation of rac‐1 a. Conditions: phosphate buffer (50 mM, pH 7.5), 30 °C, 120 rpm, 24 h (see experimental section); entries 9–10: 4 vol% MTBE; 13 μM HLADH corresponds to 0.5 mg/mL; conversions (%) to (alcohol+acid) (bold black numbers on top of the bars) and ee values were determined by chiral GC analysis after product extraction (see Supporting Information); carboxylic acid to alcohol product ratio (bold orange numbers in the bars). a) Data from ref. 7. b) After 24 h, a second aliquot of enzyme was added; total reaction time 48 h. c) After 24 h, a second aliquot of enzyme and cofactor was added; total reaction time 48 h.