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. 2018 Jul 3;57(30):9238–9261. doi: 10.1002/anie.201800343

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© 2018 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Scheme 15 — Double oxidation of alkanes to ketones. The combination of NAD(P)H‐dependent monooxygenases with NAD(P)⁺‐dependent alcohol dehydrogenases enables overall redox‐neutral reactions.