Scheme 19.

Selection of selective halogenation reactions mediated by halogenases. PCP: peptidyl carrier protein; ACP: acyl carrier protein; SyrB2: halogenase from Pseudomonas syringae;74 Barb2: halogenase from Lyngbya majuscule (involved in barbamide biosynthesis);75 CmaB: halogenase from Pseudomonas syringae (involved in coronatine biosynthesis);76 WelO5: halogenase from Hapalosiphon welwitschii (involved in welwitindolinone biosynthesis);77 CylC: non‐α‐KG‐dependent halogenase from Cylindrospermum licheniforme.78