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. 2018 Apr 14;65(2):e12491. doi: 10.1111/jpi.12491

Figure 6.

Figure 6

Adenoviral (Ad) over‐expression of SIRT1 increased PGC‐1α expression, reduced Drp1 expression and inhibited mitochondrial fission. (A) Representative confocal microscope images showing mitochondrial morphology stained by MitoTracker Red (major finding is C‐E). Original magnification ×600. (B,F‐H) Protein expressions of SIRT1, PGC‐1α, and Drp1 were determined by Western blotting. (C) The percentage of cells with fragmented mitochondria. (D) Mean volume of mitochondria (fold over NG with Ad GFP). (E) The number of mitochondria per cell. Presented values are means ± SEM. NG, normal glucose (5.5 mmol/L); HG, high glucose (33 mmol/L glucose). n = 6 in each group. *P < .05, **P < .01 vs NG with Ad GFP. ## P < .01 vs HG with Ad GFP