Skip to main content
. 2018 Feb 1;68(2):707–722. doi: 10.1002/hep.29613

Figure 6.

Figure 6

Slightly altered fat metabolism in Wls‐HECKO animals (11 weeks old; * P < 0.05; ** P < 0.01; n.s. = not significant [P > 0.05]). (A) Plasma cholesterol is lower in both male (101 mg/dL in Ctrl vs. 73 mg/dL in Wls‐HECKO) and female (59 mg/dL in Ctrl vs. 47 mg/dL in Wls‐HECKO) Wls‐HECKO mice. (B) Liver cholesterol did not differ significantly in both sexes. (C) Dry blood total acylcarnitines are significantly elevated in male Wls‐HECKO mice (3.27 vs. 3.94 nmol/mg protein). (D) Plasma triglycerides remain unchanged in all subgroups. (E) Blood glucose in male mice does not differ significantly after 4 hours of fasting. (F) Left: Bilirubin levels exceed 0.145 mg/dL in male Wls‐HECKO mice more often than in Ctrl; female mice showed no significance. Black dots represent single animal Ctrl, gray dots single animal Wls‐HECKO bilirubin levels. Right: induction of hepatic HMOX1 shown by qRT‐PCR. Fold change relative to β‐Actin is shown; Ctrl was set to 1. Bars represent SEM. Mean fold induction in Wls‐HECKO is 1.66 (P = 0.0409; n = 7).