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. 2018 Feb 1;68(2):707–722. doi: 10.1002/hep.29613

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© 2017 The Authors. Hepatology published by Wiley Periodicals, Inc. on behalf of American Association for the Study of Liver Diseases.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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RosaEvi‐YFP expression in Wls‐rescue livers. Representative pictures of immunofluorescence (63× objective) showing focal YFP (green) staining in HECs of Wls‐rescue livers (A, n = 2), strong YFP staining in HECs of Wls‐HECKO;eYFP (C, n = 5), and no YFP signal in Ctrl liver (E, n = 5). Ctrl (n = 5) and Wls‐rescue (n = 2) livers show a pericentral, membranous RhBg staining pattern in HCs (A,E), which is absent in pericentral HCs in Wls‐HECKO;eYFP (C). EMCN (green) staining is positive in CVECs and pericentral LSECs, whereas LYVE1 (red) is highly positive in midlobular LSECs of all groups (B,D,F). Glul (blue) is expressed in HCs adjacent to CVECs expressing EMCN in Wls‐rescue (B) and Ctrl (F). Wls‐HECKO;eYFP shows no signal for Glul. (F). Scale bar = 50 μm.