Table 2.

Arithmetic mean values of pharmacokinetic characteristics of empagliflozin in plasma

Characteristic	5 mg empagliflozin (N=9)		10 mg empagliflozin (N=8)		25 mg empagliflozin (N=10)
	Mean	%CV	Mean	%CV	Mean	%CV
AUC0‐∞, nmol h/l	1270	51.9	1450	17.2	5250	27.6
AUC0‐tz, nmol h/l	1240	54.2	1420	16.9	5150	27.6
AUC0‐24, nmol h/l	1110	42.7	1310	18.9	4720	27.4
Cmax, nmol/l	175	54.2	211	59.1	692	57.3
tmax *, h	1.50	0.95–7.92	1.25	0.97–4.17	1.78	0.50–4.00
t1/2, h	7.03	18.9	7.61	27.0	8.09	26.8

AUC_0‐∞, area under the plasma concentration–time curve from time 0 extrapolated to infinity; AUC_0‐tz, area under the plasma concentration–time curve from time 0 to the time of the last quantifiable concentration; AUC_0–24, area under the plasma concentration‐time curve from time 0 to 24 h post dose; C_max, maximum observed plasma concentration; CV, arithmetic coefficient of variation; t_max, time from dosing until maximum observed concentration is reached in plasma; t_1/2, terminal half‐life in plasma.

*For t_max, the median and range are given (instead of mean and %CV).